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Building evidence, including the current study, suggests that mitochondria mediated metabolite disturbances are emerging as prevalent feature in ALS, and restoration of NAD + levels by NAD+ precursor compounds could in fact be a potential therapeutic strategy for improving neuron health

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Endocr Rev 16:390410 Feinle C, Chapman IM, Wishart J, Horowitz M (2002) Plasma glucagon-like peptide-1 (GLP-1) responses to duodenal fat and glucose infusions in lean and obese men