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Conclusions Additional randomized clinical trials with clinically relevant endpoints are urgently needed to further aid in clinical decision-making, including better stratification of Graves disease patients, who are most likely to benefit from Se supplementation

Permanent effects are rare and usually linked to misuse or unregulated products

These processes include chromosomal maintenance, oxidative balance, and neuroendocrine signaling pathways

Epithalon and sleep enhancement As noted, epithalon can increase levels of melatonin, which is strongly involved in regulating the sleep cycle, thus leading to research interest in the sleep-promoting effect of epithalon [8]