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The redox effects of GSH or other thiol agents can be assessed by the use of irreversible thiol alkylating agents such as N-ethyl maleimide (NEM) which would form covalent bonds with cysteine residues and prevent further modification of these sites as has been analyzed in modulation of GABA- and glycine-evoked currents in rat retinal ganglion cells (24)
If you push too hard, try a new activity, or get hurt, muscle recovery can take longer and feel more painful
If side effects are intolerable despite management strategies, dose adjustment or alternative treatment options can be discussed
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