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The key distinction is not stability, but contamination control
The field moved from single GLP-1 receptor agonism, to dual GIP/GLP-1 agonism, and then to adding a third receptor glucagon to capture an energy-expenditure lever on top of appetite and glucose control
Nat Neurosci (2013) 16(9):12118
The benefits of metabolic surgery need to be balanced against its potential adverse effects, which vary by procedure and include surgical complications, late metabolic or nutritional complications and impact on psychological health [5, 6, 127]
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