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When combined, the inhibition of NF-B or p38 MAPK may impact ROS/RNS production and reduce the generation of cytokines in patients with IBD, particularly when the disease is actively progressing ( Figure 4 Similarly, combining TLR4/NF-B and Nrf2-ARE pathway modulation offers a comprehensive approach to managing IBD by simultaneously reducing inflammation and enhancing antioxidant defenses

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Wang, X., Chen, J., Rong, C., Pan, F., Zhao, X., & Hu, Y