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Since oxidative stress is the main cause of APAP-induced hepatotoxicity, sulforaphane protects the liver from APAP overload toxicity by activating the Nrf2 pathway and increasing the endogenous antioxidant response (Schmidt, 1984)

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Supplementation of carnitine leads to an activation of the IGF-1/PI3K/Akt signalling pathway and down regulates the E3 ligase MuRF1 in skeletal muscle of rats

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Targeting the incretin/glucagon system with triagonists An even more advanced step towards the generation of an effective anti-obesity pharmacotherapy is the report of a single peptide capable of simultaneously activating the receptors for glucagon, GLP-1, and GIP by using a highly effective, balanced triagonist structure [25]

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