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Pramlintide reduces postprandial glucose excursions when added to insulin lispro in subjects with type 2 diabetes: a dose-timing study
The pattern of results, particularly the amplification of benefit at higher weight loss thresholds, is consistent with the hypothesis that HRT restores a metabolic environment that makes GLP-1 therapy more effective: improving insulin sensitivity, preserving lean mass, reducing the inflammatory burden that blunts metabolic responsiveness, and supporting the mitochondrial function that underlies energy regulation
Intriguingly, when rats were fed a diet containing heptanoic acid (C7:0), a medium-chain fatty acid that is not biosynthesized in the body, ghrelin modified with heptanoic acid was detected in their blood (Nishi et al., 2005)
Frame GLP-1 management as a design question, not a yes-or-no question
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