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The value of the combo lies in **mechanistic divergence coupled with vascular convergence**: BPC-157 covers local cytoprotection and the gut-tendon axis, TB-500 covers systemic cell migration and stem-cell mobilization, and both converge on the neoangiogenesis required for deep tissue regeneration
In this way, it was suggested to work best for injuries in tendons, where muscle connects to bone
C.WangZ.ChoA.et al
A critical and unresolved translational question is whether the 0.4% CSF-to-plasma ratio achieved at clinical doses is sufficient to meaningfully engage central GLP-1 receptors and activate the neuroprotective pathways described in Section 5
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