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Standard GLP-1 eligibility thresholds - based on the FDA-approved drug labeling for Wegovy and Zepbound, which guides how clinicians think about the category - generally include a BMI of 30 or higher (obese), or a BMI of 27 or higher with at least one weight-related comorbidity such as high blood pressure, high cholesterol, or type 2 diabetes
JL: Conceptualization, Investigation, Writing original draft
(Interestingly, hes found that increasing the very small amount formed in the nasal systems olfactory bulb seems to amplify the motivation to eat.) His hope is that eventually we will be able to activate very specific pathways in the brain using the drug, which would allow for more narrowly targeted pharmaceutical treatments
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