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NAD+ plays a direct role in DNA repair by activating PARP-1, the enzyme that detects and fixes DNA strand breaks before they can pile up into lasting damage

The selectivity of FOXO4-DRI appears to be a major advantage: FOXO4-DRI peptide is particularly compelling due to its ability to disrupt the FOXO4-p53 interaction , a critical regulator of cellular senescence

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This action can then activate SIRT1 pathways, which are crucial for mitochondrial biogenesis and fat oxidation