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& Al Ateeq, M
1 Introduction Prader-Willi syndrome (PWS) is a rare genetic disorder characterized by impaired hypothalamic development and function with an estimated incidence of 1 per 20,000 newborns ( Patients with PWS experience complex nutritional, neurodevelopmental, metabolic and behavioral changes that drive obesity development ( Obesity management in PWS typically includes a calorie-restricted diet, strict control of food access, regular physical activity and behavioral interventions ( 2 Case series 2.1 Patient 1 A 28-year-old female with PWS, resulting from uniparental disomy, was evaluated at our Endocrinology Unit
Growth hormone and insulin-like growth factor I treatment increase testicular luteinizing hormone receptors and steroidogenic responsiveness of growth hormone deficient dwarf mice
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