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High levels of lactate in the microenvironment directly regulate the polarization of macrophages, and this effect depends on the stable expression of HIF-1, which induces the production of VEGF and the expression of M2 macrophage markers, including ARG1, found in inflammatory zone 1 (FIZZ1), macrophage galactose-C type lectin (MGL) 1 and MGL2 [357]
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