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Clinical evidence shows semaglutide does reduce abdominal fat distribution, but the degree depends on your starting weight, metabolism, and individual peptide sensitivity

[13] [9] Patients should report any changes in symptoms, particularly neurological manifestations, as these may indicate inadequate dosing or alternative diagnoses

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The focus should be on evaluating their regulatory effects on the gut microbiota structure, SCFAs metabolic profile, and cartilage ferroptosis markers (e.g., MDA, iron accumulation levels)