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In OASIS 4, gastrointestinal effects affected around 74% of those on the Wegovy pill compared with 42% on placebo, led by nausea (roughly 47% vs 19%) and vomiting (about 31% vs 6%), with diarrhoea and constipation also common
Semaglutides potent systemic effects, including improved glycemic control, weight loss, and a marked reduction in systemic inflammation (as evidenced by an approximate 30% reduction in hs-CRP in the EVOKE trials), can substantially and positively impact brain health (Athauda et al., 2026
Berwick M, Vineis P
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