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The Synergy: How They Work Together The reason these two are often called a "power couple" is due to a biological process known as the redox cycle

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This assumption was subsequently affirmed by a case report, showing that the application of TNF- monoclonal antibodies not only reduced cytokine release but also suppressed vascular endothelial growth factor production, ultimately alleviating the COVID-19 ARDS ( Cytokine antibody In ARDS pathophysiology, circulating concentrations of IL-1, IL-6, IL-8, TNF, and other cytokines are known to cause an increased pro-inflammatory effect

(2) Elsevier