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These oral agents work by stimulating the pancreatic beta cells to release more insulin, regardless of blood glucose levels
Recommended monitoring includes: Complete blood count, comprehensive metabolic panel Vitamin B12, folate, iron studies, vitamin D, calcium, parathyroid hormone Thiamine in patients with persistent vomiting Protein intake assessment and albumin/prealbumin levels Contraindications include personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2, as GLP-1 receptor agonists carry a boxed warning based on rodent studies showing thyroid C-cell tumors
The BMI threshold is important to note because this is where a lot of GLP-1 providers will differ
Mutations in the DJ-1 Gene associated with autosomal recessive early-onset Parkinsonism
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