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NNMT is overexpressed in adipose tissue of obese subjects, and its inhibition has been explored as a strategy to modulate methyl group flux and NAD+ precursor availability
86 Overall, the evidence is overwhelmingly in favour of the use of methyl-B12, alone or alongside other treatments, in diabetic neuropathy, with oral and injectable B12 showing benefits
If persistent tachycardia occurs, healthcare professionals may consider further investigations such as ECG, thyroid function tests, electrolytes and medication review
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