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Studies in the model organism Caenorhabditis elegans have demonstrated that different FOXO isoformsparticularly DAF-16Aexert a significant influence on lifespan extension by activating or repressing specific genes such as gst-20 and srr-4, which either promote or inhibit longevity-associated mechanisms
Proc Natl Acad Sci USA 97:50715076 Liu H, Wang H, Shenvi S, Hagen TM, Liu RM (2004) Glutathione metabolism during aging and in Alzheimer disease
Gorman MJ, Patel N, Guebre-Xabier M, Zhu AL, Atyeo C, Pullen KM, et al
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