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Diverse signaling pathways, such as Wnt/-catenin, Notch, and PPAR, govern intestinal stem cell proliferation and differentiation, with metabolic processes like fatty acid oxidation substantially influencing gut size and villus development, while microbiota significantly modulates intestinal structure and function, impacting morphology, motility, and nutrient absorption
Checking out the phase 3 TRIUMPH-1 topline results for #retatrutide Topline results from Eli Lilly and Company highlight a couple of things to celebrate Baseline BMI 40 means we are helping a patient population who has been marginalized previously and who have had relatively fewer options for meaningful weight loss (eg, bariatric surgery) Almost 30% mean #weightloss at the highest retatrutide dose is approximating what we achieve with #bariatricsurgery Notes of caution It's silly when companies downplay side effects with a handwaving statement of "generally consistent with trials of other incretin-based therapies" We don't have head-to-head comparison to tirzepatide, but FOR CONTEXT, tirzepatide had ~HALF the rate of constipation and vomiting Takeaways Trial design here really informs intended patient population Retatrutide 12 mg is slated to be a genuine alternative to bariatric surgery for this patient population with severe #obesity Side effect management will be key to tolerability and long-term #weightmanagement BREAKING NEWS
Most wellness-focused clients schedule IV infusions every two to four weeks, while those managing chronic fatigue or recovering from illness may benefit from weekly sessions during acute phases
Neither the participants nor researchers knew whether a participant was taking the active drug or the placebo
