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While decreased FGF21 receptor expression has been proposed to underlie this FGF21-resistant state, (73), the dramatic upregulation of fibroblast activation protein (FAP), an endopeptidase that cleaves and inactivates endogenous FGF21 (74), has been reported in liver and serum of patients with metabolic liver disease (7577)
Yes, its formulated to be gentle and soothing
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