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All substances in our combined approach (propolis, bilberry, carnitine, coenzyme Q10, silymarin, ginkgo biloba, vitamin C, vitamin E, and diclofenac) are factor NF-kB inhibitors and block production of proinflammatory cytokines [8, 26,27,28,29,30,31,32,33,34,35,36,37,38,39,40]
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Two domains of Nrf2 cooperatively bind CBP, a CREB binding protein, and synergistically activate transcription
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