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In metabolic and nutritional regulation, the GH/IGF-1 system responds dynamically to nutrient status and metabolic signals

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These activated Smads form a complex with Smad4, which translocates to the nucleus and promotes the expression of pro-fibrotic genes [24], such as Type I Collagen alpha 1 (COL1A1) and Fibronectin and Connective Tissue Growth Factor (CTGF)