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Ipamorelin, a pentapeptide ghrelin mimetic, binds to ghrelin receptors (GHS-R1a) on the same somatotrophs, synergizing with Tesamorelin to amplify GH release without stimulating ACTH or cortisol secretion the way earlier secretagogues like GHRP-6 did
Hepcidin promotes intracellular iron overload via inhibiting iron export through ferroportin blockage and ubiquitination (Kowdley et al., 2021)
Serum biochemical marker analysis As mentioned above, the cytotoxicity assays indicate that DHED possesses the strongest toxicity among all tested drugs, with an IC 50 value (27.063M) significantly lower than that of the positive control GE (131.151M)
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