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Patients should: Follow the dose escalation schedule to minimise side effects Attend regular follow-up appointments to monitor progress and safety Engage with dietetic support to ensure adequate nutrition whilst reducing calorie intake Combine medication with increased physical activity (aim for 150 minutes moderate-intensity exercise weekly, plus muscle-strengthening activities on at least 2 days per week, as per UK Chief Medical Officers' guidelines) Structured lifestyle programmes : NICE recommends multicomponent interventions including dietary modification, physical activity, and behavioural strategies

I had EVLT last January 29 on my left leg

GHK-Cu (Glycine-Histidine-Lysine Copper) is a naturally occurring copper peptide tripeptide known for its profound role in biological signaling and tissue remodeling

The area percentage (%) of tissue with fibrotic changes on Massons trichrome-stained sections was evaluated using ImageJ software (Van De Vlekkert et al., 2020)