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Besselink-Lobanova A, Maandag NJ, Voermans NC, et al
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FcRn antagonists likely block transplacental transport of IgG, as demonstrated for nipocalimab in an ex vivo placental transfusion model [341], and are unlikely to pass to the fetus, as the high affinity and limited pH-dependency of their binding to FcRn cause them to stay within FcRn-expressing cells, and not undergo extensive receptor-mediated transport
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