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Patient Counseling Information Patients must be informed that phentermine hydrochloride is a short-term (a few weeks) adjunct in a regimen of weight reduction based on exercise, behavioral modification and caloric restriction in the management of exogenous obesity, and that coadministration of phentermine with other drugs for weight loss is not recommended [see Indications and Usage (1)and Warnings and Precautions (5)]

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This slowing effect is central to the drug's appetite-suppressing properties but also has downstream consequences for bowel motility and transit time

The NHS Medicines information on fluoxetine notes that changes in appetite and weight can occur