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(2013) in rats, intra-VTA Ex-4 was found to reduce high-fat food intake (from 3 to 24 h), and these reductions were suppressed by AMPA/kainate receptor antagonist, CNQX
Mitochondrial function in GWS was investigated using muscle biopsies and three experimental protocols designed to evaluate different aspects of mitochondrial metabolism
The mechanism by which metformin leads to apoptosis through cell cycle arrest can be explained as follows: when cells are blocked at specific cycle stages, they are unable to complete the normal process of DNA replication and division, resulting in increased intracellular pressure and accumulation of DNA damage, and these changes ultimately trigger the cells apoptosis program (63)
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