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Clinical note: Dose selection and titration are determined by your provider based on your response, goals, and clinical tolerance

However, the in vivo physiological consequence of glucagon action on -cells remains uncertain, especially considering that directional flow through a pancreatic islet is from -cells to -cells, such that secreted glucagon has to complete a circuit of the body, including escaping clearance through the liver and kidney, so that minimal concentrations of glucagon actually reach the -cell and are unlikely to have a physiological effect 62,63

Slow titration and proactive management strategies help patients push through this adjustment period successfully

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