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Similarly, Jia et al (91) reported that elevated neuronal lactate uptake augments ROS production and mitochondrial oxidative metabolism, thereby disrupting the balance between ROS generation and detoxification, impairing ATP synthesis and ultimately leading to peripheral axonal degeneration
Consistent with this, we demonstrate that treatment with MK-801, even at doses that do not evoke weight loss, elicits pronounced hyperthermia in DIO mice (Extended Data Fig
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