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Direction of Future Research A multicenter randomized clinical trial is current in progress in Spain primary health-care setting called Project OB12 ( Conclusion Oral vitamin B12 replacement at 1000 g daily is an adequate alternative to IM B12 injections
As a key coenzyme in mitochondrial energy metabolism, increased NAD enhances mitochondrial oxidative phosphorylation, promotes triglyceride breakdown in adipocytes, and converts fat into energy for the body, thereby reducing adipose tissue accumulation
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Untreated vitamin B12 deficiency anemia may lead to various complications, such as heart problems, nerve damage, and developmental issues in children
