Proper refrigeration is not optionalit is the foundation of maintaining both safety and efficacy throughout your treatment month
Wake at your normal time and eat a light meal first, something with protein and minimal fat
Nonclinical Toxicology 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility In a 2-year carcinogenicity study in CD-1 mice, subcutaneous doses of 0.3, 1 and 3 mg/kg/day [2-, 11-, and 30-fold the maximum recommended human dose (MRHD) of 2 mg/week, based on AUC] were administered to the males, and 0.1, 0.3 and 1 mg/kg/day (1-, 2-, and 7-fold MRHD) were administered to the females
Thats exactly why the dosing schedule starts low and increases slowly, it gives your system time to catch up without overwhelming it