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The review also documented how GCL expression is transcriptionally upregulated by electrophiles through antioxidant response elements (ARE/EpRE) in the GCLC and GCLM promoters establishing the Nrf2/ARE pathway as the master regulator of GSH biosynthetic capacity under stress conditions
Which part of the catalytic cycle is rate-limiting for glutaredoxin catalysis
Therefore, vitamin C is easily oxidized and dehydrogenated, which makes it extremely reductive and therefore also a highly effective antioxidant
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