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Dosing protocols are not standardized

Microbiota-driven ACh dysregulation is validated in inflammatory bowel disease (IBD) models: Dysbiosis-induced choline deficiency is reversed by cytidine diphosphate (CDP)-choline supplementation, which upregulates choline transporter (ChT1), acetylcholinesterase (AChE), and 7 nicotinic acetylcholine receptor (7nAChR) expression to restore neurotransmission (Vernino et al., 2000)

When the researchers delivered GLP-1 to this brain area in mice, it reduced their desire for "rewarding food, like a burger," says Ali D

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