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Once activated, caspase-3 initiates the cleavage of a downstream substrate, such as nuclear poly (ADP-ribose) polymerase (PARP), which facilitates cellular disassembly and serves as a biomarker of cell apoptosis

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Divella R, Daniele A, De Luca R, Simone M, Naglieri E, Savino E, et al

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Press gently into skin rather than rubbing

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