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Every protocol is designed for a specific physiological outcome
Abbasiliasi, S
A compromised compound mid-study can mean restarting experiments, losing funding cycles, or submitting incomplete data
On the other hand, treatment of cancer cells with the anti-IGF-IR mAb cixutumumab paradoxically triggers cancer cells to produce IGF2, which in turn recruits macrophages and fibroblasts to promote angiogenesis and metastasis thereby hampering the efficacy of cixutumumab [190]
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