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All PKC isoforms share common structural characteristics, which include an N-terminal regulatory domain, a hinge region, a conserved kinase domain, and a C-terminal tail domain [38]
Due to a combination of host and microbial factors, NTHi persists in the lower airways of these individuals which is associated with an increased frequency of exacerbations, worsening symptoms, inflammation causing tissue damage, compositional changes to the lung microbiome and overall worse clinical prognosis (Sethi and Murphy, 2001
The figure was adapted from Mayr et al
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