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doi: 10.1210/en.2014-1675 52 AlvarezEMartinezMDRonceroIChowenJAGarcia-CuarteroBGispertJDet al

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The switch among GLP-1 users to more calorically dense foods can cause cholesterol issues, Rathi noted, and ProbioSEB CSC3, a blend of three spore-forming probiotics, consumed along with GLP-1s or otherwise, has been shown to reduce cholesterol as well. While its mostly still based on anecdotal reports, GLP-1 RA users often complain about struggling with focus and cognitive tasks, as well as low mood

Bottom line on safety: both have the same class-related side effects, mostly GI and manageable