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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation

Shank2 knockout mice (e67 KO) exhibit decreased expression levels of Gabra2 and GABA receptor-mediated inhibitory signaling, which can be reversed by treatment with allosteric modulators of GABA-ARs (99, 100)

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Eng, who worked for many years at the Bronx VA medical center, was awarded a 2013 Golden Goose award, a prize meant to honor federally-funded research that leads to major biomedical breakthroughs