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One controlled study involved 12 healthy male participants who ingested either milk and egg protein and oleic acid or water
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It is increasingly discussed in longevity and preventive-medicine circles as a way to achieve: Metabolic balance without extreme appetite suppression Sustained tolerability by avoiding gastrointestinal side effects Lower cost and simplified maintenance regimens Long-term receptor engagement for cardiometabolic and neuroprotective benefits While this approach remains off-label and under formal investigation, the biological rationale is strong: GLP-1 signaling is not binary but dose-responsive, and even partial activation may influence inflammatory, vascular, and cognitive pathways linked to aging
Funnel plots were generated for analyses involving 10 studies for visual inspection of asymmetrical distribution of data points across the vertical treatment effect axis
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