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At the time of the approval, John Sharretts, M.D., director of the Division of Diabetes, Lipid Disorders, and Obesity in the FDAs Center for Drug Evaluation and Research, said, Wegovy is now the first weight loss medication to also be approved to help prevent life-threatening cardiovascular events in adults with cardiovascular disease and either obesity or overweight

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Semaglutide (found in Ozempic and Wegovy) activates only GLP-1 receptors, while tirzepatide (found in Mounjaro and Zepbound) targets both GLP-1 and GIP receptors for a dual-action mechanism

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This tier has the highest rate of independent testing failures in community reports including product that tests as sterile water with no benzyl alcohol, sub-spec preservative concentrations, and endotoxin levels above USP limits

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