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Wistar rats (n = 20) weighing 140 -160g were randomly divided into 4 groups of 5 animals each
Poor bioavailability is more likely when the compounds violate two or more of the RO5
Our work agrees with previous findings and sheds light on metabolic changes and interactions
Increased binding was present in the hippocampus, amygdala, thalamus, midbrain, pons, and cingulate cortex, although the exact area of the cingulate cortex was not defined
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