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For example, some autoinjectors are pressed flat against the skin without pinching, while pen needles may require a skinfold
In summary, the reprogramming of hepatocytes associated with a profibrotic milieu results in loss of mature parenchymal cells, characterized by loss of the master hepatocyte transcription factor HNF4 (158, 212) and upregulation of the developmental Notch, Hippo (213), and Hedgehog (214) signaling pathways
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