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These challenges present structural constraints, as the systems themselves must be redesigned to increase production
We recommend a stepped approach
Blocking GSH synthesis in combination with JMF4073 depletes dTTP/dCTP pools to eradicate T315I-Bcr-Abl leukemia We hypothesize that reducing the GSH level to increase replication stress can render T315I-Bcr-Abl leukemia more susceptible to JMF4073 in vivo
Eating at different times each day confuses hunger hormones, creating false signals that lead to inconsistent intake
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