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In-vitro assays show the molecule is membrane-permeable, which supports the possibility of oral absorption, but the animal efficacy studies used injection, and no study has directly compared oral versus subcutaneous bioavailability

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Many patients start with weekly injections, which can be adjusted over time

It is particularly common in individuals with certain risk factors, including those who have undergone gastric or small intestine resections, have inflammatory bowel disease, use metformin or proton pump inhibitors, follow a vegan diet, or are older than 75 years