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Over-the-counter remedies such as simethicone may provide symptomatic relief for some patients, though evidence for their effectiveness is limited

doi: 10.3390/nu12082340 39 Aldana-HernandezPAzarcoya-BarreraJvan der VeenJNLeonardKAZhaoYYNelsonRet al

[9] Melanin is a dark pigment primarily responsible for skin color

This off-label use resulted in more people using the medication, especially individuals with obesity or those who simply wanted to lose weight, even though they did not have type 2 diabetes