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This dual action distinguishes tirzepatide from single GLP-1 receptor agonists and may account for its enhanced efficacy in clinical trials
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The cryo-EM structures of retatrutide-bound GLP-1R, GIPR and GCGR reveal a combination of conserved peptidereceptor interactions and receptor-specific conformations, particularly in ECL1, that enables retatrutide to execute agonism at multiple receptors
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