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Among the NLGN isoforms, NLGN1 is predominantly involved in excitatory synapse structure, transmission, and plasticity, but has minimal effects on inhibitory synapses.While its direct link to ASD remains unclear, alterations in NLGN1 expression may contribute to cognitive impairments through disruptions in synaptic plasticity and learning-related neural circuits (82)

Treatment duration typically ranges from 8-16 weeks for initial protocols

Expect to commit to regular application for minimum three months before evaluating effectiveness

PDL coating involved adding 100 g ml 1 PDL in sterile H 2 O for 30 min, followed by two washes with H 2 O and air-drying