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The dual therapy has demonstrated a greater improvement of endothelial glycocalyx thickness (a marker of endothelial dyfunction) after 12 months of treatment in comparison to insulin therapy, together with a greater reduction in arterial stiffness and a greater increase of myocardial work index, despite a similar improvement of glycemic burden [88]
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Visceral fat, the deep abdominal fat surrounding organs, behaves almost like an endocrine organ producing hormones and inflammatory signals
Kidney J
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