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More serious side effects may include severe gastrointestinal issues with the stomach, gallbladder or liver, pancreatitis, kidney failure, hypoglycemia, or depression/thoughts of suicide Zepbound (tirzepatide) causes thyroid C-cell tumors in rats, it is unknown whether it causes such tumors in humans at this time

Oxidation-sensitive residues Peptides containing cysteine, methionine, or tryptophan are particularly vulnerable to oxidation