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Compounded semaglutide is only available as an alternative to branded Ozempic and Wegovy as long as it remains on the FDA drug shortages list
-GLP-1 DPP-4, -GLP-1
it crosses the blood-CSF barrier
In a prospective real-world cohort of 194 adults with type 2 diabetes initiating semaglutide or dulaglutide, only 49% achieved 5% weight loss by 12 months meaning that just under half of treated patients did not meet the threshold conventionally defined as clinically meaningful (Vozza et al., 2025)
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